Numerous men have been taking online pharmacy for erectile dysfunction, and it was noted that Viagra does not only have an effect to a man’s sexual function, but it also has an effect on the heart. Effects of the hormonal stress to the human heart were noted to be decreased in men taking Viagra. The study, when tried on mice, was more noticeable as it had the tendency to avert and undo the harmful long-term effects of chronic hypertension on their heart.
Since Viagra has an effect to dilate genital blood vessels to maintain an erection, research was done if it has an effect on the human heart. And it was found out that it has potential benefits for the treatment of pulmonary hypertension. And this study was headed by the Johns Hopkins researchers. But before that, Viagra was never thought to have an effect on the heart.
Viagra works to dull the increased heart beat, which is a product of chemically-induced stress. It works to decrease the force needed to pump an excessive amount of blood from the heart to the body.
David Kass, M.D., a cardiologist and study senior author of Johns Hopkins study, and his researchers performed experiments on mice and noticed that Viagra is effective in blocking short-term consequences of hormonal stresses in the heart. Long-term damages of chronic hypertension on the heart is also prevented and reversed by Viagra. Negative effects of heart failure and cardiac hypertrophy on the weakened heart muscles in mouse experiments performed by David Kass, M.D. and his researchers are also reversed by Viagra, but this was not tested on human hearts yet so no solid evidence has been gathered to prove this.
To prove this, they conducted the Johns Hopkins study, and it showed that Viagra also has an effect in slowing heart rate after an injection of dobutamine. Thirty five men and women volunteered to go on the Johns Hopkins study for a period of six months. Necessary measurements of heart function like echocardiogram, electrocardiogram, and blood pressure readings were taken before and after the injection of dobutamine (dobutamine is a synthetic derivative of dopamine that increases heart rate and heart contraction). It showed increased heart rate and increased heart contraction by 150%. Then they were separated into two groups; those who took sildenafil (Viagra) and those who took sugar pill placebo. Dobutamine was again given to the individuals to see what sildenafil and sugar placebo has on the heart. It showed that the first group’s heart rate and heart contraction decreased by 50% while those from the second group increased yet again to about 150%.
The success of the Johns Hopkins study started other researchers on how sildenafil works when it comes to the immediate and long-term effects on the heart and other potential benefits they could get from sildenafil.
But these studies are not yet finished. For now, it is good to know that it inhibits the action of phosphodiesterase 5 or PDE5A from breaking down cyclic GMP, a key molecule that aids in the controlling of stress and hypertrophy of the heart.
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By: Jerry Black
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